1: (3R)-3-hydroxy-1-azabicyclo[2.2.2]octane With 18-crown-6 ether; sodium hydride in toluene; mineral oil Inert atmosphere; 2: 4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate in toluene; mineral oil T=20 - 110°C; 18 h; Inert atmosphere;

Multi-step reaction with 3 steps 1: sodium tetrahydroborate; iodine / tetrahydrofuran / 16 h / |Inert atmosphere; |Reflux2: hydrogenchloride; borane-ammonia complex / aq. phosphate buffer / 37 °C / pH 7.83: triethylamine / tetrahydrofuran / 2 h / 0 - 25 °C / |Inert atmosphere