1.1: hydrogen / [Ru(OAc)2((S)-2-Furyl-MeOBIPHEP)] / methanol / 20 h / 30 °C / 30003 Torr / Inert atmosphere 2.1: sulfuric acid / 19 h / 60 °C 2.2: 0 °C / pH 9 3.1: sodium methylate / methanol / 116 h / 20 °C 3.2: 19 h / 60 °C / pH 1 3.3: 0 °C / pH 9 View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1.1: caesium carbonate / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 41.33 h / 35 &deg;C / Inert atmosphere<br />2.1: trifluoroacetic acid / dichloromethane / 25.5 h / 20 &deg;C / Cooling<br />2.2: 67 h / 20 &deg;C<br />2.3: 5 &deg;C / pH 1.5<br /> <br /> &nbsp;