4-(4-(羟基甲基)-1H-1,2,3-噻唑-1-基)哌啶-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
copper(l) iodide; triethylamine in N,N-dimethyl-formamide T=20°C; 10 h;
参考文献
Darandale, Sunil N.; Mulla, Nayeem A.; Pansare, Dattatraya N.; Sangshetti, Jaiprakash N.; Shinde, Devanand B.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 527 - 532
反应条件
1: sodium tetrahydroborate / ethanol 2: triethylamine / dichloromethane 3: sodium azide / N,N-dimethyl-formamide / 80 °C 4: triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 10 h / 20 °C View Scheme
参考文献
Darandale, Sunil N.; Mulla, Nayeem A.; Pansare, Dattatraya N.; Sangshetti, Jaiprakash N.; Shinde, Devanand B.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 527 - 532
反应条件
1: triethylamine / dichloromethane 2: sodium azide / N,N-dimethyl-formamide / 80 °C 3: triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 10 h / 20 °C View Scheme
参考文献
Darandale, Sunil N.; Mulla, Nayeem A.; Pansare, Dattatraya N.; Sangshetti, Jaiprakash N.; Shinde, Devanand B.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 527 - 532
反应条件
1: sodium azide / N,N-dimethyl-formamide / 80 °C 2: triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 10 h / 20 °C View Scheme
参考文献
Darandale, Sunil N.; Mulla, Nayeem A.; Pansare, Dattatraya N.; Sangshetti, Jaiprakash N.; Shinde, Devanand B.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 527 - 532
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine
T=-78°C; Swern oxidation;
参考文献
Huang, Xiaoguang; Zhang, Aiqin; Chen, Dongliang; Jia, Zhenhua; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2859 - 2863
