1: N-iodo-succinimide / tetrahydrofuran / 12 h / 20 °C 2: palladium 10 on activated carbon; hydrogen / ethanol / 6 h / 20 °C 3: sodium hydroxide / ethanol; water 4: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction View Scheme

Multi-step reaction with 2 steps 1: N-iodo-succinimide / tetrahydrofuran / 12 h / 20 °C2: palladium 10 on activated carbon; hydrogen / ethanol / 6 h / 20 °C