3-beta-D-呋喃核糖基-噻唑并[4,5-d]嘧啶-2,7(3H,4H)-二酮合成路线 （共 4 条）
反应条件
ammonia in methanol T=90°C; 14 h;
参考文献
Nagahara; Anderson; Kini; Dalley; Larson; Smee; Jin; Sharma; Jolley; Robins; Cottam
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 407 - 415
反应条件
1: 1.) HMDS, (NH4)2SO4, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) pyridine, reflux, 4 h, 2.) acetonitrile, RT, 16 h 2: 46 percent / tert-butyl nitrite / tetrahydrofuran / 50 - 60 °C 3: 57 percent / ammonia / methanol / 14 h / 90 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 407 - 415
反应条件
1: 46 percent / tert-butyl nitrite / tetrahydrofuran / 50 - 60 °C 2: 57 percent / ammonia / methanol / 14 h / 90 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 407 - 415
反应条件
1: 1.) HMDS, (NH4)2SO4, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) pyridine, reflux, 4 h, 2.) acetonitrile, RT, 16 h 2: 46 percent / tert-butyl nitrite / tetrahydrofuran / 50 - 60 °C 3: 57 percent / ammonia / methanol / 14 h / 90 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 407 - 415
