反应条件
1.1: pyridine; formic acid; chlorosulphonyl isocyanate / dichloromethane / 2.33 h / 0 - 20 °C / Inert atmosphere
2.1: manganese(IV) oxide; dirhodium tetraacetate; [bis(acetoxy)iodo]benzene / dichloromethane / 18 h / 20 °C
3.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 5 - 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
4.2: 4.25 h / Inert atmosphere
4.3: 2 h / 50 °C / Inert atmosphere
5.1: sodium carbonate / dichloromethane; water
5.2: 18 h / 70 °C
6.1: pyridine / -15 - 5 °C
7.1: potassium carbonate / acetonitrile / 3.5 h / 80 °C
8.1: potassium hydroxide / 3-methyl pentan-3-ol / 18 h / 120 °C
9.1: boron tribromide / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Dillon, Barry R.; Roberts, Dannielle F.; Entwistle, David A.; Glossop, Paul A.; Knight, Craig J.; Laity, Daniel A.; James, Kim; Praquin, Celine F.; Strang, Ross S.; Watson, Christine A. L.
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 195 - 203
