乙基4-(4-联苯基)-4-氧代丁酸酯合成路线 (共 9 条)
反应条件
copper(l) iodide; lithium bromide in tetrahydrofuran T=0 - 20°C; 4 h;
参考文献
Kim, Seung-Hoi; Kim, Jong-Gyu
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 1 p. 341 - 343
参考文献
Journal of the American Chemical Society, , vol. 86, p. 4999 - 5003
反应条件
sodium carbonate in water; ethyl acetate; isopropyl alcohol T=50°C; Suzuki-Miyaura coupling; 0.00138889 h; Microchannel flow reactor;
参考文献
Yamada, Yoichi M. A.; Watanabe, Toshihiro; Beppu, Tomohiko; Fukuyama, Naoshi; Torii, Kaoru; Uozumi, Yasuhiro
Chemistry - A European Journal, 2010 , vol. 16, # 37 p. 11311 - 11319
反应条件
1: 4-bromo-1,1'-biphenyl With zinc in tetrahydrofuran T=20°C; 2 h; 2: 3-chlorocarbonyl-propionic acid ethyl ester With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 24 h;
参考文献
Bulletin of the Korean Chemical Society, , vol. 32, # 1 p. 341 - 343
反应条件
1: AlCl3 / nitrobenzene 2: H2SO4 View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 66, # 4 p. 466 - 476
参考文献
Journal of Pharmaceutical Sciences, , vol. 66, # 4 p. 466 - 476
Arzneimittel-Forschung/Drug Research, , vol. 30, # 4 a p. 695 - 702
反应条件
1: With potassium hydroxide in water 0.5 h; Reflux; 2: With hydrogenchloride in water
参考文献
Kim, Seung-Hoi; Kim, Jong-Gyu
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 1 p. 341 - 343
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5716944 A1, 1998 ;