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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
阿替莫德
合成路线
（共 11 条）
253335-95-4
→
反应条件
123018-47-3
阿替莫德
反应条件
hydrogen; nickel in ethanol Heating;
参考文献
Tanaka, Akio; Kawai, Takashi; Takabatake, Tetsuhiko; Oka, Noriko; Okamoto, Hideho; Bersohn, Malcolm
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6733 - 6737
60729-41-1
4,4-双丙基环己酮
→
反应条件
123018-47-3
阿替莫德
反应条件
1: 98 percent / H2 / 10percent Pd/C / ethyl acetate / 5 h / 2585.7 Torr / Ambient temperature 2: 89 percent / ammonium acetate, acetic acid / toluene / Heating 3: ethanol; H2O / 5 h / Heating 4: acetic acid, hydrochloric acid, H2O / 84 h / Heating 5: 89 percent / acetic anhydride / 4 h / Heating 6: Heating 7: LiAlH4 / diethyl ether / 3 h View Scheme
参考文献
Badger; Schwartz; Picker; Dorman; Bradley; Cheeseman; DiMartino; Hanna; Mirabelli
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2963 - 2970
253333-59-4
→
反应条件
123018-47-3
阿替莫德
反应条件
1.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran 2.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C 2.2: tetrahydrofuran 3.1: 93 percent / LiAlH4 / tetrahydrofuran / Heating 4.1: 95 percent / aq. HCl 5.1: 42 percent / BF3*OEt2 / 90 °C 6.1: 39 percent / hydrogen / Raney nickel / ethanol / Heating 7.1: 64 percent / BF3*OEt2 / 90 °C 8.1: 43 percent / hydrogen / Raney nickel / ethanol / Heating View Scheme
参考文献
Tanaka, Akio; Kawai, Takashi; Takabatake, Tetsuhiko; Oka, Noriko; Okamoto, Hideho; Bersohn, Malcolm
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6733 - 6737
255918-60-6
→
反应条件
123018-47-3
阿替莫德
反应条件
1.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran 2.1: 93 percent / LiAlH4 / tetrahydrofuran / Heating 3.1: 95 percent / aq. HCl 4.1: 42 percent / BF3*OEt2 / 90 °C 5.1: 39 percent / hydrogen / Raney nickel / ethanol / Heating 6.1: 64 percent / BF3*OEt2 / 90 °C 7.1: 43 percent / hydrogen / Raney nickel / ethanol / Heating View Scheme
参考文献
Tanaka, Akio; Kawai, Takashi; Takabatake, Tetsuhiko; Oka, Noriko; Okamoto, Hideho; Bersohn, Malcolm
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6733 - 6737
253333-61-8
→
反应条件
123018-47-3
阿替莫德
反应条件
1: 95 percent / aq. HCl 2: 42 percent / BF3*OEt2 / 90 °C 3: 39 percent / hydrogen / Raney nickel / ethanol / Heating 4: 64 percent / BF3*OEt2 / 90 °C 5: 43 percent / hydrogen / Raney nickel / ethanol / Heating View Scheme
参考文献
Tanaka, Akio; Kawai, Takashi; Takabatake, Tetsuhiko; Oka, Noriko; Okamoto, Hideho; Bersohn, Malcolm
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6733 - 6737
253335-94-3
→
反应条件
123018-47-3
阿替莫德
反应条件
1: 64 percent / BF3*OEt2 / 90 °C 2: 43 percent / hydrogen / Raney nickel / ethanol / Heating View Scheme
参考文献
Tanaka, Akio; Kawai, Takashi; Takabatake, Tetsuhiko; Oka, Noriko; Okamoto, Hideho; Bersohn, Malcolm
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6733 - 6737
253333-62-9
→
反应条件
123018-47-3
阿替莫德
反应条件
1: 42 percent / BF3*OEt2 / 90 °C 2: 39 percent / hydrogen / Raney nickel / ethanol / Heating 3: 64 percent / BF3*OEt2 / 90 °C 4: 43 percent / hydrogen / Raney nickel / ethanol / Heating View Scheme
参考文献
Tanaka, Akio; Kawai, Takashi; Takabatake, Tetsuhiko; Oka, Noriko; Okamoto, Hideho; Bersohn, Malcolm
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6733 - 6737
123018-62-2
4,4-正丙基环己酮
→
反应条件
123018-47-3
阿替莫德
反应条件
1: 89 percent / ammonium acetate, acetic acid / toluene / Heating 2: ethanol; H2O / 5 h / Heating 3: acetic acid, hydrochloric acid, H2O / 84 h / Heating 4: 89 percent / acetic anhydride / 4 h / Heating 5: Heating 6: LiAlH4 / diethyl ether / 3 h View Scheme
参考文献
Badger; Schwartz; Picker; Dorman; Bradley; Cheeseman; DiMartino; Hanna; Mirabelli
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2963 - 2970
130065-93-9
氰基(4,4-二丙基环己亚基)乙酸乙酯
→
反应条件
123018-47-3
阿替莫德
反应条件
1: ethanol; H2O / 5 h / Heating 2: acetic acid, hydrochloric acid, H2O / 84 h / Heating 3: 89 percent / acetic anhydride / 4 h / Heating 4: Heating 5: LiAlH4 / diethyl ether / 3 h View Scheme
参考文献
Badger; Schwartz; Picker; Dorman; Bradley; Cheeseman; DiMartino; Hanna; Mirabelli
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2963 - 2970
130065-94-0
1-(羧甲基)-4,4-二丙基环己烷羧酸
→
反应条件
123018-47-3
阿替莫德
反应条件
1: 89 percent / acetic anhydride / 4 h / Heating 2: Heating 3: LiAlH4 / diethyl ether / 3 h View Scheme
参考文献
Badger; Schwartz; Picker; Dorman; Bradley; Cheeseman; DiMartino; Hanna; Mirabelli
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2963 - 2970
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