6-氯-3,4-二氢-3-氧代-2H-1,4-苯并噁嗪-8-甲酸甲酯合成路线 （共 9 条）
反应条件
1: 79 percent / 0.78N aq. NH4Cl, Fe / toluene / 1 h / 85 - 90 °C 2: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C 3: K2CO3 / dimethylformamide / 2 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 3 p. 624 - 630
反应条件
1: 86 percent / HNO3, conc. H2SO4 / 1 h / 0 - 5 °C 2: 79 percent / 0.78N aq. NH4Cl, Fe / toluene / 1 h / 85 - 90 °C 3: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C 4: K2CO3 / dimethylformamide / 2 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 3 p. 624 - 630
反应条件
1: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C 2: K2CO3 / dimethylformamide / 2 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 3 p. 624 - 630
反应条件
iron; acetic acid T=75°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 12 p. 3774 - 3779
反应条件
1: 82.2 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h 2: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating 3: 97.5 percent / NaOH, H2 / Pd/C / H2O; ethanol / 5.5 h View Scheme
参考文献
Kawakita; Kuroita; Yasumoto; Sano; Inaba; Fukuda; Tahara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 624 - 630
反应条件
potassium carbonate in N,N-dimethyl-formamide a) RT, 3 h, b) 40-45 deg C, 1 h;
参考文献
Kawakita; Kuroita; Yasumoto; Sano; Inaba; Fukuda; Tahara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 624 - 630
反应条件
1: 82.2 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h 2: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating View Scheme
参考文献
Kawakita; Kuroita; Yasumoto; Sano; Inaba; Fukuda; Tahara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 624 - 630
反应条件
1: 82.2 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h 2: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating 3: SOCl2, DMF / 1,2-dichloro-ethane / 2 h / 60 °C 4: CHCl3 / 1 h / Ambient temperature View Scheme
参考文献
Kawakita; Kuroita; Yasumoto; Sano; Inaba; Fukuda; Tahara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 624 - 630
反应条件
1: 82.2 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h 2: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating 3: SOCl2, DMF / 1,2-dichloro-ethane / 2 h / 60 °C View Scheme
参考文献
Kawakita; Kuroita; Yasumoto; Sano; Inaba; Fukuda; Tahara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 624 - 630
