2-甲氧基吡啶-4-甲醇合成路线 （共 10 条）
反应条件
1: With hydrogenchloride in ethyl acetate T=0°C; 0.5 h; 2: With sodium hydrogencarbonate in chloroform; water; ethyl acetate
参考文献
SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1602647 A1, 2005 ;
Location in patent: Page/Page column 51 ;
反应条件
sodium tetrahydroborate; calcium chloride in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Subramanyam; Noguchi; Weinreb
Journal of Organic Chemistry, 1989 , vol. 54, # 23 p. 5580 - 5585
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 62 ;
US 6362336 B1
反应条件
24 h; Heating / reflux;
参考文献
Guo, Hongyan; Kim, Choung U.; Kim, Hae Soo; Lee, Chong-Kyo; Lee, Ill Young; Mitchell, Michael L.; Son, Jong Chan; Xu, Lianhong
Patent: US2008/70920 A1, 2008 ;
Location in patent: Page/Page column 98 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=20°C; 2: With water; sodium hydroxide in tetrahydrofuran; diethyl ether T=0°C; 1 h; Product distribution / selectivity;
参考文献
WO2011/84368 A1, ;
Page/Page column 57-58 ;
WO 2011/084368 A1
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 37 h / 0 - 40 °C 2: lithium borohydride / tetrahydrofuran / 20 h / 0 - 20 °C View Scheme
参考文献
WO2011/25851 A1, ;
WO 2011/025851 A1
反应条件
1: 1,4-dioxane / 26 h / |Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 17 p. 5235 - 5246
反应条件
pyridine; chromium(VI) oxide in dichloromethane 0.5 h; Ambient temperature;
参考文献
Subramanyam; Noguchi; Weinreb
Journal of Organic Chemistry, 1989 , vol. 54, # 23 p. 5580 - 5585
反应条件
thionyl chloride in dichloromethane T=20°C; 2 h;
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang
Patent: WO2011/84368 A1, 2011 ;
Location in patent: Page/Page column 73 ;
WO 2011/084368 A1
反应条件
1: thionyl chloride / 2.25 h / 0 °C
2: 18-crown-6 ether / acetonitrile / 13 h / 20 °C
3: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C
View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
