6-氯-7-碘-7-脱氮嘌呤合成路线 （共 13 条）
反应条件
N-iodo-succinimide; sodium sulfate in ethanol; N,N-dimethyl-formamide
反应条件
in N,N-dimethyl-formamide T=20°C;
参考文献
US2009/48189 A1, ;
Page/Page column 36 ;
反应条件
iodine in methanol; N,N-dimethyl-formamide
参考文献
US2003/187001 A1, ;
US 20030187001 A1
反应条件
1: trichlorophosphate / 5 h / Reflux 2: N-iodo-succinimide / N,N-dimethyl-formamide / 20 h / Inert atmosphere; Darkness View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 4064 - 4067
反应条件
1: sodium ethanolate / ethanol / 95 °C 2: hydrogenchloride / water / 22 h 3: ammonium hydroxide / water / 72 h / Reflux 4: trichlorophosphate / 5 h / Reflux 5: N-iodo-succinimide / N,N-dimethyl-formamide / 20 h / Inert atmosphere; Darkness View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 4064 - 4067
反应条件
1: hydrogenchloride / water / 22 h 2: ammonium hydroxide / water / 72 h / Reflux 3: trichlorophosphate / 5 h / Reflux 4: N-iodo-succinimide / N,N-dimethyl-formamide / 20 h / Inert atmosphere; Darkness View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 4064 - 4067
反应条件
1: ammonium hydroxide / water / 72 h / Reflux 2: trichlorophosphate / 5 h / Reflux 3: N-iodo-succinimide / N,N-dimethyl-formamide / 20 h / Inert atmosphere; Darkness View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 4064 - 4067
反应条件
in water; N,N-dimethyl-formamide; mineral oil
参考文献
BASF Aktiengesellschaft
Patent: US6001839 A1, 1999 ;
US 6001839 A
反应条件
in N,N-dimethyl-formamide
参考文献
Shakespeare, William C.; Sawyer, Tomi K.; Metcalf III, Chester A.; Wang, Yihan; Bohacek, Regine; Sundaramoorthi, Rajeswari
Patent: US2003/114467 A1, 2003 ;
反应条件
1: n-Bu3SnCN With tetrakis(triphenylphosphine) palladium(0) in anhydrous dichloroethane 0.5 h; Inert atmosphereReflux; 2: 4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine in anhydrous dichloroethane 24 h; RefluxInert atmosphere;
参考文献
NOVARTIS AG; CHEN, Yen-Liang; DURAISWAMY, Jeyaraj; KONDREDDI, Ravinder Reddy; YIN, Zheng
Patent: WO2010/15637 A1, 2010 ;
Location in patent: Page/Page column 96 ;
