6-氯-7-碘-7-脱氮嘌呤合成路线 （共 13 条）
反应条件
1: acetonitrile / 0.17 h / 20 °C 2: 171 mg / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 80 °C 3: 71 percent / ammonia / methanol / 120 - 130 °C View Scheme
参考文献
Ugarkar, Bheemarao G.; DaRe, Jay M.; Kopcho, Joseph J.; Browne III, Clinton E.; Schanzer, Juergen M.; Wiesner, James B.; Erion, Mark D.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2883 - 2893
反应条件
1: NaH / 24 h / 20 °C
2: 100 percent / TFA
View Scheme
参考文献
Ugarkar, Bheemarao G.; DaRe, Jay M.; Kopcho, Joseph J.; Browne III, Clinton E.; Schanzer, Juergen M.; Wiesner, James B.; Erion, Mark D.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2883 - 2893
反应条件
triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C; 16 h; Inert atmosphere;
参考文献
NOVARTIS AG
Patent: WO2008/95993 A1, 2008 ;
Location in patent: Page/Page column 58-59 ;
