(2R)-2-乙基-吡咯烷合成路线 (共 5 条)
反应条件
hydrogenchloride; water in 1,4-dioxane
T=90°C; 5 h; Sealed tube;
参考文献
GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BLACKLEDGE, Charles, William; BRADY, Gerald, Patrick; FENG, Yanhoug, G.; GRANT, Seth, W.; MEDINA, Jesus, Rahul; MILLER, William, H.; ROMERIL, Stuart, P.
Patent: WO2010/59658 A1, 2010 ;
Location in patent: Page/Page column 137 ;
WO 2010/059658 A1
反应条件
trifluoroacetic acid
T=0°C; 0.5 h; Yield given;
参考文献
Fuji, Kaoru; Node, Manabu; Nagasawa, Hideko; Naniwa, Yoshimitsu; Taga, Tooru; et al.
Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 7921 - 7925
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
T=20°C; Hydrogenolysis; P=6840.46 Torr;
参考文献
Andres, Jose M.; Herraiz-Sierra, Ignacio; Pedrosa, Rafael; Perez-Encabo, Alfonso
European Journal of Organic Chemistry, 2000 , # 9 p. 1719 - 1726
反应条件
1: CuI / diethyl ether; CH2Cl2 / 3 h / 0 °C
2: CF3COOH / 0.5 h / 0 °C
View Scheme
参考文献
Fuji, Kaoru; Node, Manabu; Nagasawa, Hideko; Naniwa, Yoshimitsu; Taga, Tooru; et al.
Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 7921 - 7925
反应条件
Yield given. Multistep reaction;
参考文献
Doyle, Michael P.; Kalinin, Alexey V.
Tetrahedron Letters, 1996 , vol. 37, # 9 p. 1371 - 1374