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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
123172-88-3
合成路线
(共 8 条)
5470-96-2
喹啉-2-甲醛
+
1530-45-6
(乙氧基羰基甲基)三苯基溴化膦
→
反应条件
123172-88-3
反应条件
potassium carbonate in dichloromethane; water T=25°C; Wittig reaction; Sonication; stereoselective reaction;
参考文献
Riccaboni, Mauro; La Porta, Elena; Martorana, Andrea; Attanasio, Roberta
Tetrahedron, 2010 , vol. 66, # 23 p. 4032 - 4039
1613-37-2
喹啉-N-氧化物
+
140-88-5
丙烯酸乙酯
→
反应条件
123172-88-3
反应条件
palladium diacetate in 1-methyl-pyrrolidin-2-one T=110°C; 20 h; regioselective reaction;
参考文献
Wu, Junliang; Cui, Xiuling; Chen, Lianmei; Jiang, Guojie; Wu, Yangjie
Journal of the American Chemical Society, 2009 , vol. 131, # 39 p. 13888 - 13889
1873-55-8
3-甲基喹啉N-氧化物
+
141-32-2
丙烯酸丁酯
+
1190232-50-8
→
反应条件
123172-88-3
+
1190232-37-1
反应条件
palladium diacetate in 1-methyl-pyrrolidin-2-one T=110°C; 20 h; chemoselective reaction;
参考文献
Wu, Junliang; Cui, Xiuling; Chen, Lianmei; Jiang, Guojie; Wu, Yangjie
Journal of the American Chemical Society, 2009 , vol. 131, # 39 p. 13888 - 13889
91-63-4
2-甲基喹啉
+
50845-77-7
2-(4-甲氧基苯基氨基)乙酸乙酯
→
反应条件
123172-88-3
反应条件
1: DL-4-methoxyphenylglycine ethyl ester With 2,3-dicyano-5,6-dichloro-p-benzoquinone in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: 2-Methyl quinoline in N,N-dimethyl-formamide T=70°C; 24 h; Inert atmosphere; diastereoselective reaction;
参考文献
Zhang, Yong-Gang; Xu, Jing-Kun; Li, Xi-Ming; Tian, Shi-Kai
European Journal of Organic Chemistry, 2013 , # 18 p. 3648 - 3652
109586-44-9
+
140-88-5
丙烯酸乙酯
→
反应条件
123172-88-3
反应条件
palladium diacetate; triethylamine; tris-(o-tolyl)phosphine in acetonitrile T=100°C; 18 h;
参考文献
Crisp, Geoffrey T.; Papadopoulos, Spiros
Australian Journal of Chemistry, 1989 , vol. 42, # 2 p. 279 - 285
5470-96-2
喹啉-2-甲醛
+
1099-45-2
乙氧甲酰基亚甲基三苯基膦
→
反应条件
123172-88-3
反应条件
in tetrahydrofuran; ethyl acetate; toluene
参考文献
Merck Frosst Canada, Inc.
Patent: US5334597 A1, 1994 ;
US 5334597 A
91-22-5
喹啉
+
140-88-5
丙烯酸乙酯
→
反应条件
123172-88-3
+
70542-20-0
反应条件
1,10-phenanthroline; palladium diacetate; silver carbonate in N,N-dimethyl-formamide T=140°C; 12 h;
参考文献
Ye, Mengchun; Gao, Guo-Lin; Yu, Jin-Quan
Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 6964 - 6967
123172-88-3
→
反应条件
945-82-4
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 20°C; 3 h;
参考文献
AbbVie Inc.; Abbott GmbH and Co. KG; Geneste, Hervé; Ochse, Michael; Drescher, Karla; Dinges, Jürgen; Jakob, Clarissa
Patent: US2013/116229 A1, 2013 ;
Location in patent: Paragraph 1048; 1049 ;