1-(三异丙基硅基)吲哚合成路线 （共 17 条）
反应条件
1: indole With sodium hydride in tetrahydrofuran T=20°C; 1 h; Inert atmosphere; 2: triisopropylsilyl chloride in tetrahydrofuran T=20°C; 1.5 h; Inert atmosphere;
参考文献
Nippon Steel and Sumikin Chemical Co., Ltd.; SAWADA Yuichi; HOTTA Masanori; MATSUMOTO Megumi
Patent: EP2628743 A1, 2013 ;
Location in patent: Paragraph 0143 ;
反应条件
triethylamine; palladium diacetate; 2-dicyclohexylphosphino-1,1'-biphenyl in 1,4-dioxane T=80°C; 2 h;
参考文献
Helvetica Chimica Acta, , vol. 89, # 5 p. 936 - 946
反应条件
3,3-dimethylbut-1-ene; RhCl(CO)(PFur3)2; caesium carbonate in 1,4-dioxane T=120°C; 14 h;
参考文献
Sezen, Bengue; Sames, Dalibor
Journal of the American Chemical Society, 2004 , vol. 126, # 41 p. 13244 - 13246
反应条件
1: 3-bromo-1-(1,1,1-triisopropylsilyl)-1H-indole With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.333333 h; 2: tert-nitrodienamine in tetrahydrofuran; pentane T=-78 - 20°C;
参考文献
Heterocycles, , vol. 53, # 12 p. 2701 - 2708
反应条件
Yield given. Multistep reaction;
参考文献
Beswick; Greenwood; Mowlem; Nechvatal; Widdowson
Tetrahedron, 1988 , vol. 44, # 23 p. 7325 - 7334
反应条件
1: NBS / tetrahydrofuran; hexane / 2 h / -78 °C 2: tert-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 3: pentane; tetrahydrofuran / 0.25 h / -78 °C 4: TBAF / tetrahydrofuran / 0.17 h / 25 °C View Scheme
参考文献
Amat, Mercedes; Sathyanarayana, Swargam; Hadida, Sabine; Bosch, Joan
Heterocycles, 1996 , vol. 43, # 8 p. 1713 - 1718
反应条件
2: 100 percent / tetrabutylammoniun fluoride / tetrahydrofuran / 0 °C View Scheme
参考文献
Beswick; Greenwood; Mowlem; Nechvatal; Widdowson
Tetrahedron, 1988 , vol. 44, # 23 p. 7325 - 7334
反应条件
1: NBS / tetrahydrofuran; hexane / 2 h / -78 °C 2: tert-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 3: pentane; tetrahydrofuran / 0.25 h / -78 °C 4: TBAF / tetrahydrofuran / 0.17 h / 25 °C View Scheme
参考文献
Amat, Mercedes; Sathyanarayana, Swargam; Hadida, Sabine; Bosch, Joan
Heterocycles, 1996 , vol. 43, # 8 p. 1713 - 1718
反应条件
1: NBS / tetrahydrofuran; hexane / 2 h / -78 °C 2: tert-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 3: pentane; tetrahydrofuran / 0.25 h / -78 °C 4: TBAF / tetrahydrofuran / 0.17 h / 25 °C View Scheme
参考文献
Amat, Mercedes; Sathyanarayana, Swargam; Hadida, Sabine; Bosch, Joan
Heterocycles, 1996 , vol. 43, # 8 p. 1713 - 1718
反应条件
Yield given. Multistep reaction;
参考文献
Beswick; Greenwood; Mowlem; Nechvatal; Widdowson
Tetrahedron, 1988 , vol. 44, # 23 p. 7325 - 7334
