N-丙基-N-[(2S)-1,2,3,4-四氢-5-甲氧基-2-萘基]-2-噻吩乙胺盐酸盐合成路线 （共 2 条）
反应条件
1: With AlCl3, aluminium chloride; thiourea in toluene 2 h; Reflux; 2: With ammonia in water; toluene T=10 - 25°C;
参考文献
WO2010/73124 A2, ;
Page/Page column 30 ;
反应条件
1: With AlCl3, aluminium chloride; thiourea in toluene T=60 - 65°C; 2: With ammonia in water; toluene T=15 - 30°C; pH=8 - 9; 3: With hydrogenchloride in dichloromethane
参考文献
ACTAVIS GROUP PTC EHF; KHUNT, Mayur, Devjibhai; VARMA, Shrikant; PATIL, Nilesh, Sudhir; PAGIRE, Haushabhau, Shivaji; PRADHAN, Nitin, Sharadchandra
Patent: WO2010/73124 A2, 2010 ;
Location in patent: Page/Page column 27-28 ;
