diethyl cyanophosphonate; triethylamine in ethylene glycol dimethyl ether T=120°C; 18 h;

sodium carbonate in water; N,N-dimethyl-formamide T=88°C; Suzuki coupling; 18 h; Inert atmosphere;

1.1: N-bromosuccinmide / acetonitrile / 18 h / 20 °C 2.1: lithium hydroxide hydrate / methanol; water / 2 h / Reflux 3.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 0.5 h 3.2: 18 h / 20 °C 4.1: sodium carbonate / water; N,N-dimethyl-formamide / 18 h / 88 °C / Inert atmosphere View Scheme

1.1: lithium hydroxide hydrate / methanol; water / 2 h / Reflux 2.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 0.5 h 2.2: 18 h / 20 °C 3.1: sodium carbonate / water; N,N-dimethyl-formamide / 18 h / 88 °C / Inert atmosphere View Scheme

1.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 0.5 h 1.2: 18 h / 20 °C 2.1: sodium carbonate / water; N,N-dimethyl-formamide / 18 h / 88 °C / Inert atmosphere View Scheme

1: water; lithium hydroxide hydrate / methanol / 2 h / 90 °C 2: triethylamine; diethyl cyanophosphonate / ethylene glycol dimethyl ether / 18 h / 120 °C View Scheme