3-硝基-4-乙酰氨基苯乙腈合成路线 （共 6 条）
反应条件
nitric acid in acetic anhydride T=-10 - 20°C; 1 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2004/76424 A1, 2004 ;
Location in patent: Page 57 ;
WO 2004/076424 A1
反应条件
2: fuming nitric acid View Scheme
参考文献
Jones et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 2843,2945
反应条件
nitric acid T=5 - 10°C;
参考文献
Phillips
Journal of the Chemical Society, 1928 , p. 2395
参考文献
Phillips
Journal of the Chemical Society, 1928 , p. 2395
反应条件
hydrogenchloride in water 48 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2004/76424 A1, 2004 ;
Location in patent: Page 57 - 58 ;
WO 2004/076424 A1
反应条件
potassium hydroxide; water
参考文献
Gabriel
Chemische Berichte, 1882 , vol. 15, p. 838
Chemische Berichte, 1882 , vol. 15, p. 3060
