(R)-2-(哌啶-3-基)乙酸乙酯盐酸盐合成路线 （共 5 条）
反应条件
hydrogenchloride in diethyl ether T=0°C; 2 h;
参考文献
Zhu, Ying-Guang; Kan, Hong-Zhu; Jiang, Li-Qin; Hu, Wen-Hao
Synthetic Communications, 2012 , vol. 42, # 8 p. 1137 - 1145
反应条件
1: acetonitrile / 12 h / Reflux 2: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 8 h / 20 °C / 7500.75 Torr 3: (S)-α-hydroxybenzeneacetic acid / ethyl acetate / 4 h / Reflux; Resolution of racemate 4: hydrogenchloride / diethyl ether / 2 h / 0 °C View Scheme
参考文献
Zhu, Ying-Guang; Kan, Hong-Zhu; Jiang, Li-Qin; Hu, Wen-Hao
Synthetic Communications, 2012 , vol. 42, # 8 p. 1137 - 1145
反应条件
1: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 8 h / 20 °C / 7500.75 Torr 2: (S)-α-hydroxybenzeneacetic acid / ethyl acetate / 4 h / Reflux; Resolution of racemate 3: hydrogenchloride / diethyl ether / 2 h / 0 °C View Scheme
参考文献
Zhu, Ying-Guang; Kan, Hong-Zhu; Jiang, Li-Qin; Hu, Wen-Hao
Synthetic Communications, 2012 , vol. 42, # 8 p. 1137 - 1145
反应条件
1: 5 Pd(II)/C(eggshell); hydrogen 2: acetonitrile / 12 h / Reflux 3: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 8 h / 20 °C / 7500.75 Torr 4: (S)-α-hydroxybenzeneacetic acid / ethyl acetate / 4 h / Reflux; Resolution of racemate 5: hydrogenchloride / diethyl ether / 2 h / 0 °C View Scheme
参考文献
Zhu, Ying-Guang; Kan, Hong-Zhu; Jiang, Li-Qin; Hu, Wen-Hao
Synthetic Communications, 2012 , vol. 42, # 8 p. 1137 - 1145
反应条件
1: thionyl chloride / 16.25 h / 0 °C / Reflux 2: acetonitrile / 12 h / Reflux 3: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 8 h / 20 °C / 7500.75 Torr 4: (S)-α-hydroxybenzeneacetic acid / ethyl acetate / 4 h / Reflux; Resolution of racemate 5: hydrogenchloride / diethyl ether / 2 h / 0 °C View Scheme
参考文献
Zhu, Ying-Guang; Kan, Hong-Zhu; Jiang, Li-Qin; Hu, Wen-Hao
Synthetic Communications, 2012 , vol. 42, # 8 p. 1137 - 1145
