1.1: RuCl3*3H2O; NaIO4 / acetonitrile; H2O 1.2: 74 percent / pyridine / 12 h 2.1: NaOMe / methanol / 12 h / 20 °C 2.2: 99 percent / aq. NaOH / 2 h / Heating View Scheme

Multi-step reaction with 2 steps 1: 54 percent / acetone / 3 h / Heating2: 75 percent / trimethyl phosphite / 5 h / Heating  

Multi-step reaction with 4 steps 1.1: 43 percent / tetrahexylammonium bromide; aq. NaOH; chiral diphosphine C44H40N2O2P2 / [η3-allylPdCl]2 / CH2Cl2 / 30 °C2.1: 99 percent / NaOMe / methanol / 24 h / 20 °C3.1: 88 percent / m-CPBA / methanol / 20 °C4.1: NaH / dimethylformamide / 0.5 h / 30 °C4.2: 68 percent / dimethylformamide / 30 °C