(E)-3-(二甲基氨基)-1-(吡啶-4-基)丙-2-烯-1-酮合成路线 （共 7 条）
反应条件
guanidino acetic acid T=100°C; 1 h;
参考文献
Bindal, Sachin; Kumar, Dinesh; Kommi, Damodara N.; Bhatiya, Sonam; Chakraborti, Asit K.
Synthesis, 2011 , # 12 art. no. C01711SS, p. 1930 - 1935
参考文献
American Cyanamid Company
Patent: US4281000 A1, 1981 ;
反应条件
hydrazine in ethanol 2.5 h;
参考文献
GENENTECH, INC.; ARRAY BIOPHARMA, INC.; LAIRD, Ellen; LYSSIKATOS, Joseph, P.; WELCH, Mike; GRINA, Jonas; HANSEN, Josh; NEWHOUSE, Brad; OLIVERO, Alan; TOPOLAV, George
Patent: WO2006/84015 A2, 2006 ;
Location in patent: Page/Page column 79-80 ;
WO 2006/084015 A2
反应条件
sodium in ethanol
RefluxInert atmosphere;
参考文献
Che, Chao; Li, Song; Yang, Bo; Xin, Shengchang; Yu, Zhixiong; Shao, Taofeng; Tao, Chuanye; Lin, Shuo; Yang, Zhen
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 841 - 849
参考文献
Dong, Hua-Ze; Feng, Xiao-Jun; Dai, Bi-Sheng; Su, Cheng-Bai; Zheng-Zheng; Wang, Lin
Asian Journal of Chemistry, 2013 , vol. 25, # 4 p. 2035 - 2037
反应条件
in ethanol
1 h; Heating / reflux;
参考文献
GENENTECH, INC.; ARRAY BIOPHARMA, INC.; LAIRD, Ellen; LYSSIKATOS, Joseph, P.; WELCH, Mike; GRINA, Jonas; HANSEN, Josh; NEWHOUSE, Brad; OLIVERO, Alan; TOPOLAV, George
Patent: WO2006/84015 A2, 2006 ;
Location in patent: Page/Page column 74 ;
WO 2006/084015 A2
反应条件
in ethanol
4 h; Heating / reflux;
参考文献
GENENTECH, INC.; ARRAY BIOPHARMA, INC.; LAIRD, Ellen; LYSSIKATOS, Joseph, P.; WELCH, Mike; GRINA, Jonas; HANSEN, Josh; NEWHOUSE, Brad; OLIVERO, Alan; TOPOLAV, George
Patent: WO2006/84015 A2, 2006 ;
Location in patent: Page/Page column 77 ;
WO 2006/084015 A2
