4-苯基-1-哌啶羧酸叔丁酯合成路线 （共 9 条）
反应条件
palladium on activated charcoal; hydrogen in methanol T=20°C; 15 h;
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
[NiCl2(1,2-dimethoxyethane)]; (+)-Norephedrine; lithium hexamethyldisilazane; water; cesium fluoride in N,N-dimethyl acetamide T=60°C; Hiyama cross-coupling; 16 h;
参考文献
Strotman, Neil A.; Sommer, Stefan; Fu, Gregory C.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 19 p. 3556 - 3558
反应条件
diethylamine in 1,2-dichloro-ethane T=20°C;
参考文献
WO2004/82682 A1, ;
Page 38; 39 ;
WO 2004/082682 A1
反应条件
bis[2-(N,N-dimethylamino)ethyl] ether; ((Me)N2N)Ni-Cl in tetrahydrofuran T=20°C; Kumada-Corriu-Tamao coupling reaction; 2 h; Inert atmosphere;
参考文献
Vechorkin, Oleg; Proust, Valerie; Hu, Xile
Journal of the American Chemical Society, 2009 , vol. 131, # 28 p. 9756 - 9766
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; zinc in N,N-dimethyl acetamide T=85°C; Negishi coupling reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 20 p. 6088 - 6092
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 2 h / 20 °C 1.3: 15 h / -78 - 20 °C 2.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 74, p. 246 - 257
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 2 h / 20 °C 1.3: 15 h / -78 - 20 °C 2.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 74, p. 246 - 257
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C; 5 h;
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C
2: sodium iodide; sodium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
3: hydrazine hydrate / ethanol / 2 h / 70 °C
View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
