N-Boc-(甲胺基)乙醛合成路线 （共 10 条）
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C; 3 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/120098 A1, 2007 ;
Location in patent: Page/Page column 88 ;
WO 2007/120098 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 2 h;
参考文献
Jukic; Mayer; Schmitt; Drapeau; Regoli; Michelot
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 921 - 928
反应条件
in dichloromethane; dimethyl sulfoxide; ethyl acetate
反应条件
1: 55 percent / DMAP / tetrahydrofuran / 19 h / 20 °C 2: 11.56 g / KH / dimethylformamide / 3.5 h / 0 - 25 °C 3: 6.38 g / O3 / methanol; CH2Cl2 / 0.5 h / -78 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 89, # 8 p. 1559 - 1573
反应条件
1: diisopropylethylamine / CH2Cl2 / 1 h / 20 °C 2: LAH / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Journal of Natural Products, , vol. 66, # 2 p. 183 - 199
反应条件
ozone in methanol; dichloromethane T=-78°C; 0.5 h;
参考文献
Nanchen, Steve; Pfaltz, Andreas
Helvetica Chimica Acta, 2006 , vol. 89, # 8 p. 1559 - 1573
反应条件
1: aq. LiOH / methanol 2: diisopropylethylamine / CH2Cl2 / 1 h / 20 °C 3: LAH / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Journal of Natural Products, , vol. 66, # 2 p. 183 - 199
反应条件
1.1: 98 percent / NaH / tetrahydrofuran / 42 h / 0 - 20 °C 2.1: N-methylmorpholine; isobutylchloroformate / CH2Cl2 / 0.25 h / -15 °C 2.2: 83 percent / CH2Cl2 / 16 h / -15 - 20 °C 3.1: 46 percent / LiAlH4 / tetrahydrofuran / 0.33 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 9 p. 1719 - 1737
反应条件
1: 11.56 g / KH / dimethylformamide / 3.5 h / 0 - 25 °C 2: 6.38 g / O3 / methanol; CH2Cl2 / 0.5 h / -78 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 89, # 8 p. 1559 - 1573
反应条件
sec.-butyllithium 1.) ether, -78 gradC, 3.5 h. 2.) -78 gradC to room temperature; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 30, # 10 p. 1197 - 1200
