1-(2-氨基-5-溴苯基)-2,2,2-三氟乙酮合成路线 （共 3 条）
反应条件
1: With sodium azide in dimethyl sulfoxide T=95°C; 1 h; 2: With SnCl2·2H2O in water; dimethyl sulfoxide; ethyl acetate T=20°C; 0.5 h;
参考文献
Janssen Pharmaceutica NV; Leonard, Kristi A.; Barbay, Kent; Edwards, James P.; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Nishimura, Rachel; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Wolin, Ronald L.; Woods, Craig R.; Fourie, Anne; Xue, Xiaohua; Mirzadegan, Taraneh; Ganamet, Kelly
Patent: US2014/107097 A1, 2014 ;
Location in patent: Paragraph 0268; 0269 ;
反应条件
sodium azide; sodium sulfate in n-heptane; water; dimethyl sulfoxide
参考文献
JANSSEN PHARMACEUTICA NV; LEONARD, KRISTI A.; BARBAY, KENT; EDWARDS, JAMES P.; KREUTTER, KEVIN D.; KUMMER, DAVID A.; MAHAROOF, UMAR; NISHIMURA, RACHEL; URBANSKI, MAUD; VENKATESAN, HARIHARAN; WANG, AIHUA; WOLIN, RONALD L.; WOODS, CRAIG R.; FOURIE, ANNE; XUE, XIAOHUA
Patent: US2014/107096 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane 2: sodium azide; sodium sulfate / water; dimethyl sulfoxide; n-heptane View Scheme
参考文献
Janssen Pharmaceutica NV; Leonard, Kristi A.; Barbay, Kent; Edwards, James P.; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Nishimura, Rachel; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Wolin, Ronald L.; Woods, Craig R.; Fourie, Anne; Xue, Xiaohua; Mirzadegan, Taraneh; Ganamet, Kelly
Patent: US2014/107097 A1, 2014 ;
