1-[(6-氟-3-吡啶基)羰基]-L-脯氨酸合成路线 （共 4 条）
反应条件
sodium hydroxide in water; acetone 15 h; Ambient temperature;
参考文献
Anderson, Wayne K.; Dean, Dennis C.; Endo, Toshiyasu
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1667 - 1675
反应条件
1: 1.) NaNO2, 2.) 48percent aq. HBF4 2: 45 percent / KMnO4 / H2O / 4.5 h / 100 °C 3: 86 percent / thionyl chloride / 25 h / Heating 4: 67 percent / NaOH / H2O; acetone / 15 h / Ambient temperature View Scheme
参考文献
Anderson, Wayne K.; Dean, Dennis C.; Endo, Toshiyasu
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1667 - 1675
反应条件
1: 45 percent / KMnO4 / H2O / 4.5 h / 100 °C 2: 86 percent / thionyl chloride / 25 h / Heating 3: 67 percent / NaOH / H2O; acetone / 15 h / Ambient temperature View Scheme
参考文献
Anderson, Wayne K.; Dean, Dennis C.; Endo, Toshiyasu
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1667 - 1675
反应条件
1: 86 percent / thionyl chloride / 25 h / Heating 2: 67 percent / NaOH / H2O; acetone / 15 h / Ambient temperature View Scheme
参考文献
Anderson, Wayne K.; Dean, Dennis C.; Endo, Toshiyasu
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1667 - 1675
