反应条件
1.1: 1,2-dichloro-ethane; benzotriazol-1-ol / dichloromethane / 0.5 h / 0 °C
1.2: 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
3.1: potassium tert-butylate / tert-butyl alcohol / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Bin, Jin Wen; Wong, Iris L. K.; Hu, Xuesen; Yu, Zhang Xiao; Xing, Li Fu; Jiang, Tao; Chow, Larry M. C.; Biao, Wan Sheng
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9057 - 9070
