1-氨基-2,2-二甲基环丙烷羧酸合成路线 （共 23 条）
反应条件
tetrapotassium pyrophosphate; sodium azide; ACC deaminase T=30°C; 288 h; enzymatic deamination of (+/-)-2-methyl-ACC;
参考文献
Honma, Mamoru; Kirihata, Mitsunori; Uchimura, Yuka; Ichimoto, Itsuo
Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 4 p. 659 - 661
反应条件
tetrapotassium pyrophosphate; sodium azide; ACC deaminase T=30°C; 288 h; enzymatic deamination of (+/-)-2-methyl-ACC;
参考文献
Honma, Mamoru; Kirihata, Mitsunori; Uchimura, Yuka; Ichimoto, Itsuo
Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 4 p. 659 - 661
反应条件
hydrogenchloride 444 h; Heating;
参考文献
Kimpe, Norbert De; Sulmon, Paul; Brunet, Pascal
Journal of Organic Chemistry, 1990 , vol. 55, # 22 p. 5777 - 5784
反应条件
Yield given. Multistep reaction;
参考文献
De Kimpe; Sulmon; Boeykens
Tetrahedron, 1991 , vol. 47, # 20-21 p. 3389 - 3406
反应条件
Yield given. Multistep reaction;
参考文献
De Kimpe; Sulmon; Boeykens
Tetrahedron, 1991 , vol. 47, # 20-21 p. 3389 - 3406
反应条件
1: 90 percent / Et3N / CH2Cl2 / Ambient temperature
View Scheme
参考文献
De Kimpe; Sulmon; Boeykens
Tetrahedron, 1991 , vol. 47, # 20-21 p. 3389 - 3406
反应条件
1: 93 percent / Et3N / CH2Cl2 / Ambient temperature
View Scheme
参考文献
De Kimpe; Sulmon; Boeykens
Tetrahedron, 1991 , vol. 47, # 20-21 p. 3389 - 3406
反应条件
1: 90 percent / oxalic acid / methanol; H2O / Ambient temperature
2: 90 percent / Et3N / CH2Cl2 / Ambient temperature
View Scheme
参考文献
De Kimpe; Sulmon; Boeykens
Tetrahedron, 1991 , vol. 47, # 20-21 p. 3389 - 3406
反应条件
1: 82 percent / oxalic acid / methanol; H2O / Ambient temperature
2: 93 percent / Et3N / CH2Cl2 / Ambient temperature
View Scheme
参考文献
De Kimpe; Sulmon; Boeykens
Tetrahedron, 1991 , vol. 47, # 20-21 p. 3389 - 3406
反应条件
1: 72 percent / titanium tetrachloride / diethyl ether
2: 83 percent / potassium t-butoxide / tetrahydrofuran / 2 h / Heating
3: 82 percent / aq. oxalic acid / Ambient temperature
4: CH2Cl2 / Ambient temperature
5: RuO2, NaIO4 / acetone; H2O
6: H3O(1+) / H2O / 6 h / Heating
View Scheme
参考文献
Kimpe, Norbert De; Sulmon, Paul; Schamp, Niceas
Tetrahedron Letters, 1989 , vol. 30, # 37 p. 5029 - 5032
