1-氨基-2,2-二甲基环丙烷羧酸合成路线 （共 23 条）
反应条件
1: 1.) TosCl; 2.) LiCl / 1.) pyridine; 2.) DMF
2: 72 percent / titanium tetrachloride / diethyl ether
3: 83 percent / potassium t-butoxide / tetrahydrofuran / 2 h / Heating
4: 82 percent / aq. oxalic acid / Ambient temperature
5: CH2Cl2 / Ambient temperature
6: RuO2, NaIO4 / acetone; H2O
7: H3O(1+) / H2O / 6 h / Heating
View Scheme
参考文献
Kimpe, Norbert De; Sulmon, Paul; Schamp, Niceas
Tetrahedron Letters, 1989 , vol. 30, # 37 p. 5029 - 5032
反应条件
1: 1.) TosCl; 2.) LiCl / 1.) pyridine; 2.) DMF
2: 93 percent / titanium tetrachloride / diethyl ether
3: 97 percent / potassium t-butoxide / tetrahydrofuran / 2 h / Heating
4: 90 percent / aq. oxalic acid / Ambient temperature
5: CH2Cl2 / Ambient temperature
6: RuO2, NaIO4 / acetone; H2O
7: H3O(1+) / H2O / 6 h / Heating
View Scheme
参考文献
Kimpe, Norbert De; Sulmon, Paul; Schamp, Niceas
Tetrahedron Letters, 1989 , vol. 30, # 37 p. 5029 - 5032
反应条件
1: 97 percent / potassium t-butoxide / tetrahydrofuran / 2 h / Heating
2: 90 percent / aq. oxalic acid / Ambient temperature
3: CH2Cl2 / Ambient temperature
4: RuO2, NaIO4 / acetone; H2O
5: H3O(1+) / H2O / 6 h / Heating
View Scheme
参考文献
Kimpe, Norbert De; Sulmon, Paul; Schamp, Niceas
Tetrahedron Letters, 1989 , vol. 30, # 37 p. 5029 - 5032
反应条件
1: 83 percent / potassium t-butoxide / tetrahydrofuran / 2 h / Heating
2: 82 percent / aq. oxalic acid / Ambient temperature
3: CH2Cl2 / Ambient temperature
4: RuO2, NaIO4 / acetone; H2O
5: H3O(1+) / H2O / 6 h / Heating
View Scheme
参考文献
Kimpe, Norbert De; Sulmon, Paul; Schamp, Niceas
Tetrahedron Letters, 1989 , vol. 30, # 37 p. 5029 - 5032
反应条件
hydrogenchloride
120 h; Heating;
参考文献
De Kimpe, Norbert; Sulmon, Paul; Brunet, Pascal; Lambein, Fernand; Schamp, Niceas
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1863 - 1866
反应条件
hydrogenchloride
72 h; Heating;
参考文献
De Kimpe; Sulmon; Stevens
Tetrahedron, 1991 , vol. 47, # 26 p. 4723 - 4738
反应条件
hydrogenchloride in toluene
1.) 60 deg C, 30 min, 2.) reflux; Yield given;
参考文献
De Kimpe, Norbert; Boeykens, Marc; Tehrani, Kourosch Abbaspour
Journal of Organic Chemistry, 1994 , vol. 59, # 26 p. 8215 - 8219
反应条件
1: 86 percent / 1 N NaOH / methanol / 15 h / Ambient temperature
2: Et3N, diphenyl phosphoroazidate / toluene / 1 h / Heating
3: 8 N aq. HCl / toluene / 1.) 60 deg C, 30 min, 2.) reflux
View Scheme
参考文献
De Kimpe, Norbert; Boeykens, Marc; Tehrani, Kourosch Abbaspour
Journal of Organic Chemistry, 1994 , vol. 59, # 26 p. 8215 - 8219
反应条件
1: Et3N, diphenyl phosphoroazidate / toluene / 1 h / Heating
2: 8 N aq. HCl / toluene / 1.) 60 deg C, 30 min, 2.) reflux
View Scheme
参考文献
De Kimpe, Norbert; Boeykens, Marc; Tehrani, Kourosch Abbaspour
Journal of Organic Chemistry, 1994 , vol. 59, # 26 p. 8215 - 8219
反应条件
hydrogenchloride
72 h; Heating; Yields of byproduct given;
参考文献
Kimpe, Norbert De; Sulmon, Paul; Brunet, Pascal
Journal of Organic Chemistry, 1990 , vol. 55, # 22 p. 5777 - 5784
