(2E)-3-[2-(三氟甲基)苯基]丙烯醛合成路线 （共 5 条）
反应条件
1: With zinc dibromide in tetrahydrofuran 2: With water; zinc(II) chloride in tetrahydrofuran; diethyl ether T=10 - 20°C; 1 h;
参考文献
ANGION BIOMEDICA CORP.
Patent: WO2004/58721 A2, 2004 ;
Location in patent: Page 91 ;
反应条件
1.1: sodium hydride / ethylenediamine; mineral oil / 0 °C / Inert atmosphere 1.2: 0.5 h / Inert atmosphere 2.1: diisobutylaluminium hydride / toluene / 0.5 h / 0 °C / Inert atmosphere 3.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere View Scheme
参考文献
Barcelos, Rosimeire Coura; Pastre, Julio Cezar; Caixeta, Vanessa; Vendramini-Costa, Debora Barbosa; De Carvalho, Joao Ernesto; Pilli, Ronaldo Aloise
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3635 - 3651
反应条件
1: diisobutylaluminium hydride / toluene / 0.5 h / 0 °C / Inert atmosphere 2: manganese(IV) oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere View Scheme
参考文献
Barcelos, Rosimeire Coura; Pastre, Julio Cezar; Caixeta, Vanessa; Vendramini-Costa, Debora Barbosa; De Carvalho, Joao Ernesto; Pilli, Ronaldo Aloise
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3635 - 3651
反应条件
Yield given. Multistep reaction;
参考文献
Nudelman, Abraham; Binnes, Yitschak; Shmueli-Broide, Naomi; Odessa, Yael; Hieble, J. Paul; Sulpizio, Anthony C.
Archiv der Pharmazie, 1996 , vol. 329, # 3 p. 125 - 132
参考文献
Liu, Jin; Boarman, Kelly Jo
Chemical Communications, 2005 , # 3 p. 340 - 341
