1: in dichloromethane T=0 - 20°C; Inert atmosphere; 2: With water in dichloromethane T=70°C; 0.166667 h; 3: With sodium hydroxide in water 1 h;
参考文献
KARUS THERAPEUTICS LIMITED; SHUTTLEWORTH, Stephen Joseph; CECIL, Alexander Richard Liam; HILL, Thomas James; SILVA, Franck Alexandre
Patent: WO2011/21038 A1, 2011 ;
Location in patent: Page/Page column 19; 24-25 ;
WO 2011/021038 A1
1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 75 °C / Inert atmosphere 2.1: dichloromethane / 0 - 20 °C / Inert atmosphere 2.2: 0.17 h / 70 °C 2.3: 1 h View Scheme
参考文献
KARUS THERAPEUTICS LIMITED; SHUTTLEWORTH, Stephen Joseph; CECIL, Alexander Richard Liam; HILL, Thomas James; SILVA, Franck Alexandre
Patent: WO2011/21038 A1, 2011 ;
WO 2011/021038 A1
