5-氟-2-(三氟甲氧基)苯胺合成路线 (共 4 条)
反应条件
1: With sulfuric acid; nitric acid T=0°C; 1.16667 h; 2: With hydrogen; nickel in methanol P=2068.65 Torr; 5 h;
参考文献
SANOFI-AVENTIS; CHOI-SLEDESKI, Yong-Mi; GARDNER, Charles, J.; LIANG, Guyan; POLI, Gregory, B.; SHUM, Patrick, Wai-Kwok; STOKLOSA, Gregory, T.; ZHAO, Zhicheng
Patent: WO2011/22449 A1, 2011 ;
Location in patent: Page/Page column 46-47 ;
WO 2011/022449 A1
反应条件
hydrogenchloride; hydrogen; palladium 10 on activated carbon in ethanol P=2585.81 Torr; 3.5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/46120 A2, 2004 ;
Location in patent: Page 191 ;
WO 2004/046120 A2
反应条件
iron; acetic acid Heating;
参考文献
Clark, Robert D.
Journal of Agricultural and Food Chemistry, 1996 , vol. 44, # 11 p. 3643 - 3652
反应条件
1: 75 percent / conc. H2SO4, HNO3 / 0 - 5 °C 2: aq. AcOH, Fe / Heating View Scheme
参考文献
Clark, Robert D.
Journal of Agricultural and Food Chemistry, 1996 , vol. 44, # 11 p. 3643 - 3652