1: With trifluorormethanesulfonic acid in acetonitrile T=20°C; 3 h; 2: With manganese triacetate in acetic acid; acetonitrile T=20°C; 24 h;

di-isopropylperoxydicarbonate in benzene T=60°C;

1: With trimethylsilyl trifluoromethanesulfonate in N,N-dimethyl-formamide T=0°C; Fridlaender reaction; HeatingSealed; 2: With water in N,N-dimethyl-formamide T=20°C; Fridlaender reaction; 1 h; Sonication;

1: With trimethylsilyl iodide in N,N-dimethyl-formamide T=0°C; Fridlaender reaction; HeatingSealed; 2: With water in N,N-dimethyl-formamide T=20°C; Fridlaender reaction; 1 h; Sonication;

1: 4-chloro-benzoyl chloride; phenylacetylene With copper(l) iodide; Pd2(PPh3)2Cl2; triethylamine in tetrahydrofuran T=20°C; Sonogashira coupling-Michael addition-cyclocondensation-sulfur extrusion; 1 h; Inert atmosphereCombinatorial reaction / High throughput screening (HTS); 2: 2-amino-benzenethiol With acetic acid in tetrahydrofuran; isopropyl alcohol T=150°C; Sonogashira coupling-Michael addition-cyclocondensation-sulfur extrusion; 1 h; Microwave irradiationInert atmosphereCombinatorial reaction / High throughput screening (HTS); regiospecific reaction;

potassium hydroxide in poly(ethylene glycol)-400 T=80°C;

1: With trimethylsilyl iodide in N,N-dimethyl-formamide T=0°C; Fridlaender reaction; HeatingSealed; 2: With water in N,N-dimethyl-formamide T=20°C; Fridlaender reaction; 1 h; Sonication;

gold(III) chloride in methanol T=20°C; 96 h;

oxygen in chloroform-d1

1: air / 1 h / 60 °C 2: anhydrous iron chloride / 1,2-dichloro-ethane / 12 h / 120 °C View Scheme