1: (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate With sodium carbonate in n-heptane; water; ethyl acetate T=15°C; pH=7.2; 0.333333 h; 2: phosgene With sodium carbonate in n-heptane; water; ethyl acetate T=12°C; 1.5 h; Product distribution / selectivity;

1: (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate With sodium carbonate in n-heptane; water; ethyl acetate T=15°C; pH=~ 9; 0.0833333 h; 2: trichloromethyl chloroformate With sodium carbonate in n-heptane; water; ethyl acetate T=12°C; 1.5 h; Product distribution / selectivity;

1: (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate With sodium carbonate in n-heptane; water; ethyl acetate T=15°C; pH=6.1; 0.333333 h; 2: bis(trichloromethyl) carbonate With sodium carbonate in n-heptane; water; ethyl acetate T=12°C; 1.5 h; Product distribution / selectivity;

1: (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate With sodium carbonate in n-heptane; water; ethyl acetate T=15°C; pH=7.2; 0.333333 h; 2: phosgene T=12 - 20°C; 1.5 h; Product distribution / selectivity;

1: (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate With sodium carbonate in n-heptane; water; ethyl acetate T=15°C; pH=6.1; 0.333333 h; 2: bis(trichloromethyl) carbonate T=12°C; 1 h; Product distribution / selectivity;

1: (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate With sodium carbonate in n-heptane; water; ethyl acetate T=15°C; 0.0833333 h; 2: trichloromethyl chloroformate T=12°C; 1.5 h; Product distribution / selectivity;