N-[2-(环己氧基)-4-硝基苯基]甲烷磺酰胺合成路线 （共 4 条）
反应条件
1: 2-cyclohexyloxy-4-nitroaniline With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: methanesulfonyl chloride in N,N-dimethyl-formamide T=20°C; 3: With sodium hydroxide T=80 - 90°C;
参考文献
Su, Bin; Diaz-Cruz, Edgar S.; Landini, Serena; Brueggemeier, Robert W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1413 - 1419
反应条件
1.1: 5 percent / K2CO3 / dimethylformamide / 120 h / Heating 2.1: NaH / dimethylformamide / 0.33 h 2.2: 20 °C 3.1: aq. KOH / 2 h / Heating View Scheme
参考文献
Su, Bin; Diaz-Cruz, Edgar S.; Landini, Serena; Brueggemeier, Robert W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1413 - 1419
反应条件
1.1: 5 percent / K2CO3 / dimethylformamide / 120 h / Heating 2.1: NaH / dimethylformamide / 0.33 h 2.2: 20 °C 3.1: aq. KOH / 2 h / Heating View Scheme
参考文献
Su, Bin; Diaz-Cruz, Edgar S.; Landini, Serena; Brueggemeier, Robert W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1413 - 1419
反应条件
1.1: NaH / dimethylformamide / 0.33 h 1.2: 20 °C 2.1: aq. KOH / 2 h / Heating View Scheme
参考文献
Wang, Min; Lacy, Gabrielle; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 332 - 336
