deltaN-苄氧羰基阿利吉仑合成路线 （共 24 条）
反应条件
2-ethyl-1-hexanoic acid in di-isopropyl ether T=60°C; SolventReagent/catalyst;
参考文献
CHEMO IBERICA, S. A.; CARCONE, Luca; MAGRONE, Domenico; BARRECA, Giuseppe; RASPARINI, Marcello; LI MING, Huan
Patent: WO2013/14191 A1, 2013 ;
Location in patent: Page/Page column 17; 18 ;
反应条件
triethylamine in dichloromethane T=20°C; 1 h;
参考文献
REDX PHARMA LIMITED; CRAIGHEAD, Mark; PALIN, Ronald; MURRAY, Neil; LINDSAY, Derek
Patent: WO2012/63085 A2, 2012 ;
Location in patent: Page/Page column 126-127 ;
WO 2012/063085 A2
反应条件
triethylamine in dichloromethane T=20°C; 1 h;
参考文献
Craighead, Mark; Palin, Ronald; Murray, Neil; Lindsay, Derek
Patent: US2013/225594 A1, 2013 ;
Location in patent: Paragraph 0494; 0494 ;
反应条件
2-hydroxy-pyridine in tert-butyl methyl ether T=65°C;
参考文献
Slade, Joel; Liu, Hui; Prashad, Mahavir; Prasad, Kapa
Tetrahedron Letters, 2011 , vol. 52, # 33 p. 4349 - 4352
反应条件
1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux 1.2: 2 h / -78 °C 1.3: -78 °C 2.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydroxide; water / ethanol / 3 h / 50 °C 3.2: 20 °C 3.3: pH 1 - 2 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme
反应条件
1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux 1.2: 2 h / -78 °C 1.3: -78 °C 2.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydroxide; water / ethanol / 3 h / 50 °C 3.2: 20 °C 3.3: pH 1 - 2 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme
反应条件
1.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 2.1: sodium hydroxide; water / ethanol / 3 h / 50 °C 2.2: 20 °C 2.3: pH 1 - 2 3.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme
反应条件
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere 1.2: 3 h / -40 - -10 °C / Inert atmosphere 2.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Reflux; Inert atmosphere 2.2: 6 h / -78 - -35 °C / Inert atmosphere 2.3: -35 °C / Inert atmosphere 3.1: hydrogenchloride; hydrogen; acetic acid / palladium 10 on activated carbon / water / 3 h / 20 °C / 760.05 Torr 4.1: sodium hydrogencarbonate / water; tetrahydrofuran 4.2: 20 °C 5.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme
反应条件
1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Reflux; Inert atmosphere 1.2: 6 h / -78 - -35 °C / Inert atmosphere 1.3: -35 °C / Inert atmosphere 2.1: hydrogenchloride; hydrogen; acetic acid / palladium 10 on activated carbon / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydrogencarbonate / water; tetrahydrofuran 3.2: 20 °C 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme
反应条件
1.1: hydrogenchloride; hydrogen; acetic acid / palladium 10 on activated carbon / water / 3 h / 20 °C / 760.05 Torr 2.1: sodium hydrogencarbonate / water; tetrahydrofuran 2.2: 20 °C 3.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme
