4-溴-3,5-二氟苯甲腈合成路线 （共 4 条）
反应条件
1: With sulfuric acid; acetic acid; sodium nitrite T=20°C; 1 h; 2: With hydrogen bromide; copper(I) bromide in water T=20°C; Sandmeyer Reaction; 13.5 h;
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
sodium nitrite; copper(I) bromide in hydrogen bromide; acetic acid
参考文献
Seiko Epson Corporation
Patent: US5354502 A1, 1994 ;
反应条件
sulfuric acid; sodium nitrite in methanol; hydrogen bromide; acetic acid; acetone
参考文献
Seiko Epson Corporation
Patent: US4883609 A1, 1989 ;
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 1.5 h / |Reflux 2.1: sodium nitrite; sulfuric acid; acetic acid / 1 h / 20 °C 2.2: 13.5 h / 20 °C View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
