1: With hydrogenchloride; water T=30 - 90°C; 2: With sodium hydroxide in water T=40 - 47°C; pH=4;

1: Et3N / Pd(OAc)2, tri-o-tolylphosphine / acetonitrile / Heating 2: H2 / <Rh(1,5-COD)(R,R-DIPAMP)>BF4 / ethyl acetate / 60 °C 3: 48percent HBr / Heating View Scheme

1: H2 / <Rh(1,5-COD)(R,R-DIPAMP)>BF4 / ethyl acetate / 60 °C 2: 48percent HBr / Heating View Scheme

hydrogen iodide 3 h; Reflux;

1.1: pyridine / 10 °C 1.2: 39 - 55 °C / Large scale reaction 2.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine 3.1: [Rh(1,5-COD)(S,S-Et-FerroTANE)]BF4; hydrogen / ethyl acetate / 16 h / 60 °C / 3750.38 Torr 4.1: hydrogenchloride; water / 30 - 90 °C 4.2: 40 - 47 °C / pH 4 View Scheme

1.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine 2.1: [Rh(1,5-COD)(S,S-Et-FerroTANE)]BF4; hydrogen / ethyl acetate / 16 h / 60 °C / 3750.38 Torr 3.1: hydrogenchloride; water / 30 - 90 °C 3.2: 40 - 47 °C / pH 4 View Scheme

1.1: [Rh(1,5-COD)(S,S-Et-FerroTANE)]BF4; hydrogen / ethyl acetate / 16 h / 60 °C / 3750.38 Torr 2.1: hydrogenchloride; water / 30 - 90 °C 2.2: 40 - 47 °C / pH 4 View Scheme

1.1: hydrogenchloride; KIO3; potassium iodide / methanol; water / 0 - 20 °C / Large scale reaction 2.1: pyridine / 10 °C 2.2: 39 - 55 °C / Large scale reaction 3.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine 4.1: [Rh(1,5-COD)(S,S-Et-FerroTANE)]BF4; hydrogen / ethyl acetate / 16 h / 60 °C / 3750.38 Torr 5.1: hydrogenchloride; water / 30 - 90 °C 5.2: 40 - 47 °C / pH 4 View Scheme

hydrogenchloride; acylase I from porcine kidney T=35°C; pH=8; 72 h; Enzymatic reaction; enantioselective reaction;

acylase I from porcine kidney; cobalt(II) chloride; sodium hydroxide T=40°C; pH=8; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;