4-(喹啉-2-甲基氧基)苯甲酸合成路线 （共 2 条）
反应条件
1: thionyl chloride / chloroform / Inert atmosphere
2: triethylamine / dichloromethane
View Scheme
参考文献
Tu, Zhude; Fan, Jinda; Li, Shihong; Jones, Lynne A.; Cui, Jinquan; Padakanti, Prashanth K.; Xu, Jinbin; Zeng, Dexing; Shoghi, Kooresh I.; Perlmutter, Joel S.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1666 - 1673
反应条件
1.1: thionyl chloride / chloroform / Inert atmosphere
2.1: triethylamine / dichloromethane
3.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice
3.2: -78 °C
4.1: 1 h / Reflux
5.1: hydrazine hydrate / methanol / 1 h / Reflux
6.1: sulfuric acid / ethanol / 1 h / Reflux
View Scheme
参考文献
Tu, Zhude; Fan, Jinda; Li, Shihong; Jones, Lynne A.; Cui, Jinquan; Padakanti, Prashanth K.; Xu, Jinbin; Zeng, Dexing; Shoghi, Kooresh I.; Perlmutter, Joel S.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1666 - 1673
