5-羟甲基异噁唑-3-甲酸乙酯合成路线 （共 14 条）
反应条件
1: 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 4: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 5: 40 percent / diethylaminosulfur trifluoride (DAST) / CH2Cl2 / 1 h / -65 - 20 °C View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 92 percent / Claisen's alkali / methanol / 0.5 h / 0 °C
2: 76 percent / K2CO3 / dimethylformamide / 7 h / 20 °C
View Scheme
参考文献
Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Kim, Dong Chan; Shin, Kye Jung; Paik, Young-Sook; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 231 - 234
反应条件
1: 92 percent / Claisen's alkali / methanol / 0.5 h / 0 °C
2: 76 percent / K2CO3 / dimethylformamide / 7 h / 20 °C
3: 56 percent / PPh3; CBr4 / CH2Cl2 / 0.5 h / -20 °C
View Scheme
参考文献
Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Kim, Dong Chan; Shin, Kye Jung; Paik, Young-Sook; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 231 - 234
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=-15°C; 2 h;
参考文献
Mao, Jialin; Yuan, Hai; Wang, Yuehong; Wan, Baojie; Pieroni, Marco; Huang, Qingqing; Van Breemen, Richard B.; Kozikowski, Alan P.; Franzblau, Scott G.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 6966 - 6978
