(R)-2-苄基-3-羟基丙酸合成路线 （共 15 条）
反应条件
1: Jones reagent / acetone / 0.17 h / 0 °C
2: LiOH / tetrahydrofuran; H2O / 1 h / 0 °C
View Scheme
参考文献
Monteil; Danvy; Plaquevent; Duhamel; Gros; Schwartz; Lecomte
Synthetic Communications, 2001 , vol. 31, # 2 p. 211 - 218
反应条件
1: With lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water
T=0 - 20°C; 2.5 h;
2: With hydrogenchloride in water
pH=2;
参考文献
McKinnel, Robert M.; Sasikumar, Vivek; Choi, Seok-Ki; Fatheree, Paul R.; Hegde, Sharath; Hudson, Ryan; Jendza, Keith; Marquess, Daniel
Patent: US2008/188533 A1, 2008 ;
Location in patent: Page/Page column 44 ;
US 20080188533 A1
反应条件
potassium carbonate in methanol; ethyl acetate; acetone
参考文献
Kaneka Corporation
Patent: US6121477 A1, 2000 ;
反应条件
1: lipase PS Amano / 48 h / 25 °C
2: Jones reagent / acetone / 0.17 h / 0 °C
3: LiOH / tetrahydrofuran; H2O / 1 h / 0 °C
View Scheme
参考文献
Monteil; Danvy; Plaquevent; Duhamel; Gros; Schwartz; Lecomte
Synthetic Communications, 2001 , vol. 31, # 2 p. 211 - 218
反应条件
1: 73 percent / Jones' reagent / acetone
2: 90 percent / methanol; K2CO3; water / 2 h / 20 °C
3: 86 percent / acetyl chloride / 24 h / 20 °C
4: phosphate buffer; α-chymotrypsin; sodium hydroxide / 18 h / pH 7.5 / Enzymatic reaction
View Scheme
参考文献
Kim, Dong H.; Park, Jeong-il; Chung, Sang J.; Park, Jung Dae; Park, No-Kyung; Han, Jong Hoon
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 8 p. 2553 - 2560
反应条件
1: 89 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating
2: lipase PS Amano / 48 h / 25 °C
3: Jones reagent / acetone / 0.17 h / 0 °C
4: LiOH / tetrahydrofuran; H2O / 1 h / 0 °C
View Scheme
参考文献
Monteil; Danvy; Plaquevent; Duhamel; Gros; Schwartz; Lecomte
Synthetic Communications, 2001 , vol. 31, # 2 p. 211 - 218
反应条件
1: Jones reagent
2: aq. HCl / tetrahydrofuran
View Scheme
参考文献
Atsuumi, Shugo; Nakano, Masato; Koike, Yutaka; Tanaka, Seiichi; Ohkubo, Mitsuru; Yonezawa, Toshiko; Funabashi, Hiroshi; Hashimoto, Junko; Morishima, Hajime
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1601 - 1604
反应条件
1: iPr2NEt / CH2Cl2
2: K2CO3 / methanol; H2O
3: Jones reagent
4: aq. HCl / tetrahydrofuran
View Scheme
参考文献
Atsuumi, Shugo; Nakano, Masato; Koike, Yutaka; Tanaka, Seiichi; Ohkubo, Mitsuru; Yonezawa, Toshiko; Funabashi, Hiroshi; Hashimoto, Junko; Morishima, Hajime
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1601 - 1604
反应条件
Rhodococcus erythropolis AJ270 cells in phosphate buffer
T=30°C; pH=7.0; Title compound not separated from byproducts.;
参考文献
Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang
Tetrahedron Asymmetry, 2008 , vol. 19, # 3 p. 322 - 329
反应条件
1.1: dihydrogen peroxide; lithium hydroxide hydrate / tetrahydrofuran; water / 0 °C
1.2: pH 2.5
2.1: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C
View Scheme
参考文献
Choi, Seung-Su; Ji, Ae-Ri; Yu, Seung-Woo; Cho, Bong-Hwan; Park, Jung Dae; Park, Jun Hyoung; Lee, Hyun Soo; Ryu, Seong Eon; Kim, Dong Han; Kang, Jae-Hoon; Lee, Seung-Taek
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 6 p. 2032 - 2038
