(2R,4R)-4-甲基-1-{[(2-甲基-2-丙基)氧基]羰基}-2-哌啶羧酸合成路线 (共 5 条)
反应条件
sodium hydroxide in tert-butyl alcohol 24 h; Ambient temperaturepH at 9.5;
参考文献
Shuman, Robert T.; Ornstein, Paul L.; Paschal, Jonathan W.; Gesellchen, Paul D.
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 738 - 741
反应条件
1: dimethylcarbamyl chloride / CH2Cl2 / 24 h / Ambient temperature 2: 93 percent / 6 N HCl / 24 h / Heating 3: 92 percent / hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr 4: 66 percent / 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5 View Scheme
参考文献
Shuman, Robert T.; Ornstein, Paul L.; Paschal, Jonathan W.; Gesellchen, Paul D.
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 738 - 741
反应条件
1: 93 percent / 6 N HCl / 24 h / Heating 2: 92 percent / hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr 3: 66 percent / 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5 View Scheme
参考文献
Shuman, Robert T.; Ornstein, Paul L.; Paschal, Jonathan W.; Gesellchen, Paul D.
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 738 - 741
反应条件
1: 92 percent / hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr 2: 66 percent / 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5 View Scheme
参考文献
Shuman, Robert T.; Ornstein, Paul L.; Paschal, Jonathan W.; Gesellchen, Paul D.
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 738 - 741
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether T=-90 - 20°C; 5 h; Product distribution; Further Variations:Reaction partners;
参考文献
Cossy, Janine; Belotti, Damien
Tetrahedron Letters, 2001 , vol. 42, # 11 p. 2119 - 2120