N-羟基奎宁环-3-羧酰胺合成路线 （共 2 条）
反应条件
hydroxylamine hydrochloride; sodium methylate in methanol 18 h; Heating;
参考文献
Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735
反应条件
1: 74 percent / t-BuOK, EtOH / 1,2-dimethoxy-ethane / 1.) 5-10 deg C, 0.5 h, 2.) 40 deg C, 2.5 h 2: 46 percent / NH2OH*HCl, MeONa / methanol / 18 h / Heating View Scheme
参考文献
Saunders, John; Cassidy, Mark; Freedman, Stephen B.; Harley, Elizabeth A.; Iversen, Leslie L.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1128 - 1138
