2,6-二氟-4-甲氧基苯甲酸合成路线 （共 12 条）
反应条件
sodium chloride; aluminium chloride in ice-water
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2.5 h;
参考文献
Gray, G. W.; Hird, M.; Lacey, D.; Toyne, K. J.
Molecular Crystals and Liquid Crystals (1969-1991), 1989 , vol. 172, p. 165 - 190
反应条件
1: 3,5-difluoroanisole With n-butyllithium in tetrahydrofuran T=-78°C; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C;
参考文献
Fray, M. Jonathan; Allen, Paul; Bradley, Paul R.; Challenger, Clare E.; Closier, Michael; Evans, Tim J.; Lewis, Mark L.; Mathias, John P.; Nichols, Carly L.; Po-Ba, Yvonne M.; Snow, Hayley; Stefaniak, Mark H.; Vuong, Hannah V.
Heterocycles, 2006 , vol. 67, # 2 p. 489 - 494
反应条件
1.1: 100 percent / potasssium carbonate / acetone / 5 h / 40 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C 2.2: 81 percent / 2 h / -78 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 1 p. 95 - 98
反应条件
[Rh(OH)(cycloocta-1,5-diene)]2; 1,3-bis-(diphenylphosphino)propane; water; sodium hydroxide in toluene T=110°C; 12 h; Inert atmosphere;
参考文献
Sun, Zhong-Ming; Zhang, Jing; Zhao, Pinjing
Organic Letters, 2010 , vol. 12, # 5 p. 992 - 995
反应条件
1: oxalyl chloride, DMF / benzene / Ambient temperature 2: 81 percent / 35percent ammonia / bis-(2-methoxy-ethyl) ether / Ambient temperature 3: 95 percent / thionyl chloride / dimethylformamide / Ambient temperature 4: 94 percent / aluminum chloride, sodium chloride / hexane; tetrahydrofuran / 1 h / 180 °C View Scheme
参考文献
Gray, G. W.; Hird, M.; Lacey, D.; Toyne, K. J.
Molecular Crystals and Liquid Crystals (1969-1991), 1989 , vol. 172, p. 165 - 190
反应条件
1.1: (COCl)2 / CH2Cl2 / 20 °C 1.2: 71 percent / aq. NH3 / tetrahydrofuran 2.1: 87 percent / (CF3CO)2O; pyridine / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Gray, G. W.; Hird, M.; Lacey, D.; Toyne, K. J.
Molecular Crystals and Liquid Crystals (1969-1991), 1989 , vol. 172, p. 165 - 190
反应条件
1.1: thionyl chloride / dimethylformamide / 2 h / Heating 2.1: sodium azide / H2O; acetone / 0.5 h / 20 °C 2.2: 660 mg / toluene / 0.5 h / Heating View Scheme
参考文献
Alonso-Alija, Cristina; Michels, Martin; Peilstoecker, Karen; Schirok, Hartmut
Tetrahedron Letters, 2004 , vol. 45, # 1 p. 95 - 98
反应条件
1: With oxalyl dichloride in dichloromethane T=20°C; 2: With ammonium hydroxide in tetrahydrofuran
参考文献
Fray, M. Jonathan; Allen, Paul; Bradley, Paul R.; Challenger, Clare E.; Closier, Michael; Evans, Tim J.; Lewis, Mark L.; Mathias, John P.; Nichols, Carly L.; Po-Ba, Yvonne M.; Snow, Hayley; Stefaniak, Mark H.; Vuong, Hannah V.
Heterocycles, 2006 , vol. 67, # 2 p. 489 - 494
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in benzene
Ambient temperature;
参考文献
E.I. DU PONT DE NEMOURS AND COMPANY; GOPALSAMUTHIRAM, Vijayagopal
Patent: WO2011/51958 A1, 2011 ;
Location in patent: Page/Page column 36 ;
