(6-氯-3-硝基-吡啶-2-基)-乙腈合成路线 （共 5 条）
反应条件
hydrogenchloride in tetrahydrofuran; dichloromethane; acetic acid
参考文献
PFIZER INC.
Patent: EP436333 A2, 1991 ;
反应条件
hydrogenchloride; HI in tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate
参考文献
Pfizer Inc.
Patent: US5051412 A1, 1991 ;
反应条件
1: With sodium hydride in N,N-dimethyl-formamide; mineral oil T=-10°C; 3 h; Inert atmosphere; 2: With hydrogenchloride in water; N,N-dimethyl-formamide; mineral oil
参考文献
Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 24 p. 8206 - 8220
反应条件
1: K2CO3 / tetrahydrofuran / 24 h / Heating 2: TsOH / toluene / 2 h / Heating View Scheme
参考文献
Katz, R. B.; Voyle, M.
Synthesis, 1989 , # 4 p. 314 - 316
反应条件
hydrogen in ethanol T=20°C; P=760.051 Torr; 3 h;
参考文献
Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 24 p. 8206 - 8220
