(1S,3R,4S,4aS,7S,8S,8aS)-4-氯-8-{2-[(2R,4R)-4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-6-氧代四氢-2H-吡喃-2-基]乙基}-4A-羟基-3,7-二甲基-1,2,3,4,4A,7,8,8A-八氢-1-萘基2,2-二甲基丁酸酯合成路线 （共 5 条）
→
123852-10-8(1S,3R,4S,4aS,7S,8S,8aS)-4-氯-8-{2-[(2R,4R)-4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-6-氧代四氢-2H-吡喃-2-基]乙基}-4A-羟基-3,7-二甲基-1,2,3,4,4A,7,8,8A-八氢-1-萘基2,2-二甲基丁酸酯
反应条件
1: imidazole / dimethylformamide 2: CH2Cl2 / -78 °C 3: 30percent H2O2 / tetrahydrofuran / 0 deg C to r.t. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 7 p. 1966 - 1968
→
123852-10-8(1S,3R,4S,4aS,7S,8S,8aS)-4-氯-8-{2-[(2R,4R)-4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-6-氧代四氢-2H-吡喃-2-基]乙基}-4A-羟基-3,7-二甲基-1,2,3,4,4A,7,8,8A-八氢-1-萘基2,2-二甲基丁酸酯
反应条件
1: imidazole / dimethylformamide 2: CH2Cl2 / -78 °C 3: 30percent H2O2 / tetrahydrofuran / 0 deg C to r.t. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 7 p. 1966 - 1968
→
123852-10-8(1S,3R,4S,4aS,7S,8S,8aS)-4-氯-8-{2-[(2R,4R)-4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-6-氧代四氢-2H-吡喃-2-基]乙基}-4A-羟基-3,7-二甲基-1,2,3,4,4A,7,8,8A-八氢-1-萘基2,2-二甲基丁酸酯
反应条件
1: CH2Cl2 / -78 °C 2: 30percent H2O2 / tetrahydrofuran / 0 deg C to r.t. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 7 p. 1966 - 1968
123852-10-8(1S,3R,4S,4aS,7S,8S,8aS)-4-氯-8-{2-[(2R,4R)-4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-6-氧代四氢-2H-吡喃-2-基]乙基}-4A-羟基-3,7-二甲基-1,2,3,4,4A,7,8,8A-八氢-1-萘基2,2-二甲基丁酸酯
→
反应条件
1: 92 percent / tri-n-butyltin hydride, AIBN / benzene / Heating 2: I2, HgO, pyridine / CCl4 / Ambient temperature 3: (n-Bu3Sn)2, pyridine / benzene / Heating; Irradiation View Scheme
参考文献
Lee; Hoffman; Holtz; Smith
Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 1966 - 1968
123852-10-8(1S,3R,4S,4aS,7S,8S,8aS)-4-氯-8-{2-[(2R,4R)-4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-6-氧代四氢-2H-吡喃-2-基]乙基}-4A-羟基-3,7-二甲基-1,2,3,4,4A,7,8,8A-八氢-1-萘基2,2-二甲基丁酸酯
→
反应条件
1: 92 percent / tri-n-butyltin hydride, AIBN / benzene / Heating 2: I2, HgO, pyridine / CCl4 / Ambient temperature 3: (n-Bu3Sn)2, pyridine / benzene / Heating; Irradiation 4: 58 percent / 48percent HF / acetonitrile / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 7 p. 1966 - 1968
