4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二羧酸 3-甲酯合成路线 （共 4 条）
反应条件
1: 2,2,6-trimethyl-4H-1,3-dioxin-4-one With 3-hydroxy-propionitrile T=120°C; 3 h; oil bath; 2: 2,3-dichlorobenzylaldehyde; methyl 3-aminocrotonate in isopropyl alcohol T=20°C; Reflux; 3: With sodium hydroxide in dichloromethane T=20°C;
参考文献
ALPHORA RESEARCH INC.; SOUZA, Fabio; PAN, Ming
Patent: WO2011/130852 A1, 2011 ;
Location in patent: Page/Page column 6 ;
反应条件
1: propan-2-ol / 5 h / Heating 2: 79 percent / Bu4NF / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Ogawa; Nakato; Tsuchida; Hatayama
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 108 - 116
反应条件
1: propan-2-ol / 5 h / Heating 2: 79 percent / Bu4NF / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Ogawa; Nakato; Tsuchida; Hatayama
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 108 - 116
反应条件
1: 70.8 percent / propan-2-ol / 3 h 2: 72 percent / 5N NaOH / acetone / 2 h / Ambient temperature View Scheme
参考文献
Ogawa; Nakato; Tsuchida; Hatayama
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 108 - 116
