N-Boc-4-哌啶甲醇合成路线 （共 71 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in dichloromethane T=20°C; 3 h;
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
Location in patent: Page/Page column 52-53 ;
反应条件
1: 100 percent / ClCOCOCl; DMSO; Et3N / CH2Cl2 2: NaCNBH3; CF3CH2OH; 3A sieves View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
1: 100 percent / ClCOCOCl; DMSO; Et3N / CH2Cl2 2: NaCNBH3; CF3CH2OH; 3A sieves 3: 100 percent / CF3COOH / CH2Cl2 View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
1: 100 percent / ClCOCOCl; DMSO; Et3N / CH2Cl2 2: NaCNBH3; CF3CH2OH; 3A sieves View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
1: 100 percent / ClCOCOCl; DMSO; Et3N / CH2Cl2 2: NaCNBH3; CF3CH2OH; 3A sieves View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
1: 100 percent / ClCOCOCl; DMSO; Et3N / CH2Cl2 2: NaCNBH3; CF3CH2OH; 3A sieves View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane Swern oxidation;
参考文献
Muehlhausen, Ute; Ermert, Johannes; Herth, Matthias M.; Coenen, Heinz H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 1 p. 6 - 12
反应条件
sodium hydroxide; triethylamine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; dimethyl sulfoxide; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US6303593 B1, 2001 ;
US 6303593 B1
反应条件
tetrapropylammonium perruthennate; 4A molecular sieves in dichloromethane T=20°C; 1 h;
参考文献
Apodaca, Richard L.; Dvorak, Curt A.; Shah, Chandravadan R.; Xiao, Wei
Patent: US2004/87573 A1, 2004 ;
Location in patent: Page 22 ;
US 20040087573 A1
反应条件
aq. NaOH in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6399619 B1, 2002 ;
US 6399619 B1
