N-Boc-4-哌啶甲醇合成路线 （共 71 条）
反应条件
sodium hydroxide in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6265434 B1, 2001 ;
US 6265434 B1
反应条件
1: Et3N / CH2Cl2 / 0 °C 2: NaN3 / dimethylformamide / Heating 3: 100 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
DONG-A PHARM.CO., LTD.; KIM, Soon-Hoe; IM, Weon-Bin; CHOI, Sung-Hak; CHOI, Sun-Ho; SOHN, Ju-Hee; SUNG, Hyun-Jung; KIM, Mi-Yeon; CHO, Kang-Hun; SOHN, Tae-Kyoung
Patent: WO2011/132901 A2, 2011 ;
WO 2011/132901 A2
反应条件
1: N-tert-butyloxycarbonyl-4-hydroxymethylpiperidine With methanesulfonyl chloride; triethylamine in acetonitrile 2: potassium cyanide in ethanol Heating / reflux;
参考文献
Sorensen, Jan Lindy; Andersen, Knud Erik; Pettersson, Ingrid
Patent: US2005/107434 A1, 2005 ;
Location in patent: Page/Page column 17 ;
US 20050107434 A1
反应条件
1: triethylamine / tetrahydrofuran; water / 0.67 h / |Inert atmosphere; |Cooling with ice 2: water; ethanol / 24 h / 80 °C View Scheme
参考文献
KOWA CO., LTD.; Morimoto, Toshiharu; Koshizawa, Tomoaki; Watanabe, Gen; Ohgiya, Tadaaki; Yamasaki, Nao; Inoue, Noriyuki
Patent: US2013/102621 A1, 2013 ;
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=0 - 20°C; 22 h;
参考文献
CURIS, INC.
Patent: WO2006/50506 A1, 2006 ;
Location in patent: Page/Page column 120-121 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Inert atmosphere; 2: With water; sodium hydroxide in tetrahydrofuran T=0 - 20°C;
参考文献
BIOVITRUM AB (publ)
Patent: WO2009/147219 A1, 2009 ;
Location in patent: Page/Page column 23 ;
WO 2009/147219 A1
反应条件
pyridine T=0 - 20°C; 16 h;
参考文献
Chiesi Farmaceutici S.p.A.; RANCATI, Fabio; Rizzi, Andrea; Linney, Ian; Blackaby, Wesley; Knight, Chris
Patent: US2013/34504 A1, 2013 ;
Location in patent: Paragraph 0147; 0148; 0149 ;
反应条件
in diethyl ether; tert-butyl methyl ether
参考文献
AstraZeneca AB
Patent: US7235559 B1, 2007 ;
US 7235559 B1
反应条件
in diethyl ether; tert-butyl methyl ether
参考文献
AstraZeneca AB
Patent: US2004/48881 A1, 2004 ;
US 20040048881 A1
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C;
参考文献
SCHERING CORPORATION; TING, Pauline, C.; LEE, Joe, F.; ASLANIAN, Robert, G.
Patent: WO2011/31628 A1, 2011 ;
Location in patent: Page/Page column 72 ;
WO 2011/031628 A1
