4-(4-羟基-1-丁炔基)苯甲酸甲酯合成路线 （共 13 条）
反应条件
1: 100 percent / H2 / Pd/C / methanol / 12 h / 2327.17 - 2585.74 Torr
2: 63 percent / aq. CrO3; sulfuric acid / acetone / 0 - 20 °C
3: oxalyl chloride / CH2Cl2 / 1 h / Heating
View Scheme
参考文献
Gangjee, Aleem; Zeng, Yibin; McGuire, John J.; Mehraein, Farideh; Kisliuk, Roy L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6893 - 6901
反应条件
With hydrogen; palladium on activated charcoal in ethanol P=2585.7 Torr; 12 h;
参考文献
Taylor; Harrington Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3222 - 3227
反应条件
Multi-step reaction with 3 steps 1: 2.60 g / H2 / 5percent palladium-on-charcoal / ethanol / 12 h / 2585.7 Torr2: triethylamine / diethyl ether / 4 h / 0 - 20 °C3: 1.) NaH / 1.) THF, 0 deg C -> room temperature, 2.) room temperature, 12 h; reflux, 6 h
参考文献
Taylor, Edward C.; Harrington, Philip M.; Shih, Chuan Heterocycles, 1989 , vol. 28, # 2 p. 1169 - 1178
