4-(4-羟基丁基)苯甲酸甲酯合成路线 (共 13 条)
反应条件
1: 63 percent / aq. CrO3; sulfuric acid / acetone / 0 - 20 °C
2: oxalyl chloride / CH2Cl2 / 1 h / Heating
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参考文献
Gangjee, Aleem; Zeng, Yibin; McGuire, John J.; Mehraein, Farideh; Kisliuk, Roy L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6893 - 6901
反应条件
With hydrogen; palladium on activated charcoal in ethanol P=2585.7 Torr; 12 h;
参考文献
Taylor; Harrington Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3222 - 3227
反应条件
Multi-step reaction with 2 steps 1: triethylamine / diethyl ether / 4 h / 0 - 20 °C2: 1.) NaH / 1.) THF, 0 deg C -> room temperature, 2.) room temperature, 12 h; reflux, 6 h
参考文献
Taylor, Edward C.; Harrington, Philip M.; Shih, Chuan Heterocycles, 1989 , vol. 28, # 2 p. 1169 - 1178